CBD increased tumor cell death in leukemia and colon cancer.
CBD also decreased human glioma cell growth and invasion, thus suggesting a possible role of CBD as an antitumor agent.
Cannabinoids may be promising tools in combination therapy for breast and prostate cancer, due to their direct antitumor effects, their ability to improve the efficacy of conventional antitumor drugs, and their usefulness as palliative treatment.
Cannabidiol May Help with Quitting Smoking
Research suggests that inhaling cannabidiol for a week might reduce the number of cigarettes smoked by about 40%, without increasing craving for nicotine
Cannabidiol Reduces Inflammation and Autoimmunity
CBD reduces the growth of neutrophils, and their migration to a target.
CBD also reduced the production of chemokines such as macrophage inflammatory protein-1 alpha (MIP-1 alpha) and macrophage inflammatory protein-1 beta (MIP-1 beta) by B-cells (R).
Macrophages from animals treated with CBD produced higher levels of interleukin-12 (IL-12) and lower levels of IL-10.
Due to its anti-inflammatory role, CBD is a very promising therapeutic agent for a variety of inflammatory and pain-associated disorders.
CBD decreased the production and release of inflammatory cytokines such as Th1 (TNF-alpha, IFN-gamma, and IL-6), Th2 (IL-4), and IL-8.
Cannabidiol May Help with Insomnia
Research suggests that taking CBD before bed improves sleep in people with insomnia
Cannabidiol May Protect the Nervous System and Helps with Neurodegenerative Diseases
CBD was found to prevent toxic effects of neurotransmitter glutamate and radical oxygen species (ROS) in the brain, thus preventing brain cell death.
CBD has antioxidant activity greater than vitamin C (ascorbic acid) or vitamin E (α-tocopherol)
CBD may also protect brain cells from beta-amyloid toxicity, making it a potential therapeutic agent in Alzheimer’s and Parkinson’s disease.
CBD may also protect the brain from ischemia.
Early human studies showed a dose-related improvement in patients with Parkinson’s disease treated with 100–600 mg/day of CBD over a 6-week period.
CBD has been shown to reverse cognitive deficits of Alzheimer’s disease in animal models.
CBD, due to its anti-inflammatory and antioxidant properties, may be a promising agent to treat and prolong survival in Amyotrophic Lateral Sclerosis (ALS) patients.
Cannabidiol May Relieve Multiple Sclerosis Symptoms
Cannabis derivatives may relieve symptoms in multiple sclerosis patients.
CBD is effective and well tolerated in the treatment of muscle tightness, pain, sleep disturbances, and urinary incontinence in people with multiple sclerosis
Cannabidiol Has Therapeutic Potential for Schizophrenia
CBD is a potential treatment for psychosis.
CBD improves the symptoms of schizophrenia. However, what regions of the brain are affected and the mechanism of action producing this dynamic are unknown
Studies suggest that CBD has a pharmacological effect similar to that of atypical anti-psychotic drugs, but with fewer side effects.
Cannabidiol May Provide Treatment for Acne
Another promising use for CBD is as a new treatment for acne. Acne is caused, in part, by inflammation and overworked sebaceous glands on the body.A recent studyposted to the Journal of Clinical Investigation found that CBD helps to lower the production of sebum that leads to acne, partly because of its anti-inflammatory effect on the body.
CBD could be a future treatment for acne vulgaris, the most common form of acne.
Cannabidiol May Treat Depression
According to researchers, CBD has antidepressant-like effects
Study found that antidepressant effects of CBD were fast, continuous over time, and comparable to a common tricyclic medication imipramine
Cannabidiol Reduces Anxiety
Cannabidiol reduces anxiety in both healthy individuals and patients with social anxiety disorder.
Studies showed that CBD significantly reduced anxiety and discomfort caused by public speaking.
CBD also reduced anxiety caused by the use of THC.
Researchers suggest that it may be effective for panic disorder, obsessive compulsive disorder and post-traumatic stress disorder
CBD is a potential therapy for posttraumatic stress disorder (PTSD) treatment.
Cannabidiol Relieves Pain
Studies suggest that cannabinoids may be a new class of drugs for the treatment of chronic pain.
CBD significantly decreased chronic inflammatory and neuropathic pain.
Cannabidiolshows promising results for the treatment of postoperative pain, chronic pain associated with multiple sclerosis, cancer, rheumatoid arthritis and neuropathic pain.
Cannabidiol May Provide Treatment for Alzheimer's disease
Initial research published in the Journal of Alzheimer’s Disease found that CBD was able to prevent the development of social recognition deficit in subjects.
This means that CBD could potentially prevent people in the early stages of Alzheimer’s from losing their ability to recognize the faces of people that they know. This is the first evidence that CBD has potential to prevent Alzheimer’s disease
Cannabidiol May Be Beneficial in Rheumatoid Arthritis
Due to its anti-inflammatory effect, cannabinoids may provide relief of joint pain and swelling, and decrease joint destruction and disease progression.
Administration of CBD protected joints against severe damage, decreased progression and produced improvement of arthritis in animal models.
The first controlled trial showed that administration of Sativex over five weeks produced significant improvements in intensity of pain on movement and at rest, quality of sleep, and inflammation. No serious adverse effects were observed.
Cannabidiol Relieves Nausea and Increases Appetite
Study showed that CBD relieved nausea and vomiting.
Researchers found that CBD in low doses decreases nausea and vomiting produced by toxic drugs.
According to the National Cancer Institute, CBD increases appetite by binding to cannabinoid receptors in the body
Cannabidiol Lowers Incidence of Diabetes
The study which included 4,657 adult men and women showed that current CBD use was associated with 16% lower fasting insulin levels, and smaller waist circumferences, a factor connected to the onset of diabetes.
Cannabidiol significantly reduces the development of diabetes in young non-obese mice, from 86% in non-treated mice to only 30% in mice treated with CBD.
Cannabidiol can inhibit and delay the destruction of insulin-producing pancreatic cells and the production of inflammatory cytokines in diabetics.
This data strengthen assumptions that CBD, which is known to be safe in man, can possibly be used as a therapeutic agent for treatment of type 1 diabetes at an early stage of the disease.
Cannabidiol May Help with Epileptic Seizures
CBD may be a promising therapy for treatment-resistant epilepsy.
In a survey including parents of children with treatment-resistant epilepsy, 84% of parents reported a reduction in their child’s seizure frequency while taking CBD.
These children also experienced increased alertness, better mood and improved sleep; drowsiness and fatigue occurred as side effects.
After 3 months of treatment with a purified 98% oil-based CBD extract, 39% of children with treatment-resistant epilepsy had a more than a 50% reduction in seizures.
Out of 8 patients, suffering from secondary generalized epilepsy resistant to antiepileptic drugs, 7 had improvement of their disease state after receiving 200-300 mg/d of cannabidiol for as long as 4.5 months.
Cannabidiol May Help with Inflammatory Bowel Disease
Studies confirmed that CBD prevents colitis in animal models of IBD
CBD may reduce inflammation and relieve symptoms of IBD such as abdominal pain, diarrhea and reduced appetite
Studies also showed that CBD may be a good candidate to normalize gut motility in patients with inflammatory bowel disease
CBD may reduce gut inflammation severity through activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma)
Cannabidiol May Play a Role in Psoriasis
CBD reduces the growth of skin cells (keratinocytes), playing a potential role in the treatment of psoriasis
Cannabidiol May be Effective for Treating Substance Use Disorders
Studies suggest that CBD may be therapy for substance use disorders.
CBD reduced the rewarding effects of morphine and reduced drug seeking of heroin
There is some promising evidence that CBD use may help people to quit smoking. A pilot study posted to Addictive Behaviors found that smokers who used an inhaler containing the compound CBD smoked fewer cigarettes but did not have any additional craving for nicotine.
Another similar study posted to Neurotherapeutics found that CBD may be a promising substance for people who abuse opioids.
Researchers noted that some symptoms experienced by patients with substance use disorders may be reduced by CBD. These include anxiety, mood symptoms, pain, and insomnia.
These are early findings, but they suggest that CBD may be used to avoid or reduce withdrawal symptoms.